Daptomycin Resistance Occurs Predominantly in vanA-Type Vancomycin-Resistant Enterococcus faecium in Australasia and Is Associated With Heterogeneous and Novel Mutations

L Li; C Higgs; AM Turner; Y Nong; CL Gorrie; NL Sherry; KH Dyet; T Seemann; DA Williamson; TP Stinear; BP Howden; GP Carter

Journal article

Daptomycin Resistance Occurs Predominantly in vanA-Type Vancomycin-Resistant Enterococcus faecium in Australasia and Is Associated With Heterogeneous and Novel Mutations

L Li, C Higgs, AM Turner, Y Nong, CL Gorrie, NL Sherry, KH Dyet, T Seemann, DA Williamson, TP Stinear, BP Howden, GP Carter

Frontiers in Microbiology | Published : 2021

DOI: 10.3389/fmicb.2021.749935

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Abstract

Healthcare associated infections caused by vancomycin-resistant Enterococcus faecium (VREfm) have a major impact on health outcomes. VREfm is difficult to treat because of intrinsic and acquired resistance to many clinically used antimicrobials, with daptomycin being one of the few last line therapeutic options for treating multidrug-resistant VREfm. The emergence of daptomycin-resistant VREfm is therefore of serious clinical concern. Despite this, the impact that daptomycin-resistant VREfm have on patient health outcomes is not clearly defined and knowledge on the mechanisms and genetic signatures linked with daptomycin resistance in VREfm remains incomplete. To address these knowledge gaps..

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University of Melbourne Researchers

Lucy Li Author

Claire Gorrie Author

Norelle Sherry Author

Torsten Seemann Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The project was supported by National Health and Medical Research Council (NHMRC) of Australia funding (GNT1185213, GNT1160745, and GNT1105905). MDU PHL was funded by the Victorian Government, Australia and ESR was funded by the New Zealand Ministry of Health, who funded the collection of New Zealand isolates. A subgroup of isolates was collected as part of a project funded by Melbourne Genomics Health Alliance.